Microdosing Mushrooms vs Microdosing LSD

Virtually any psychedelic substance can be used for microdosing. But perhaps due to their popularity in mainstream culture and the relative ease of obtaining them, medicinal mushrooms and LSD seem to be the two most common psychedelics used by modern day microdosers.

While microdosing research and reports of self-experimentation have shed light on the potential benefits of microdosing, little if any research has been conducted on the difference between microdosing mushrooms and microdosing LSD. However, the two can produce very different experiences, and one substance may be better than the other for your individual goals, desires, and body composition. Based on what we know so far, here are some of the key differences between microdosing mushrooms and microdosing LSD.


One of the most apparent differences between mushrooms and LSD is that mushrooms come from the earth, while LSD is synthesized in a lab. While one is not necessarily better than the other, this distinction plays into the decisions of many microdosers.

Some may be more comfortable microdosing mushrooms because they are natural. It may feel less like a drug and carry less stigma and shame, which is why some people prefer it to LSD.

On the other hand, some may prefer the clean, synthetic nature of LSD, especially if they trust that it’s coming from a reputable lab.

Neither of these psychedelics comes without risks. There’s a chance your mushrooms could be the wrong type, and either not work or cause undesirable effects. Growing your own mushrooms from spores, purchasing legal psilocybin truffles, or purchasing mushrooms from someone else who grows them can mitigate this risk.

With LSD, there’s the risk you might have been sold a different drug. It’s important to both know exactly where your LSD is coming from and use a reagent kit to test for other substances. Substances like NBOMe can sometimes be sold as LSD, and can be harmful to your health. NBOMe has a distinct bitter taste which is easier to detect with a full dose, but much harder with a microdose.


Another difference to consider is the ease of preparing each of these substances for a microdosing regimen.

Two common methods for microdosing LSD include cutting up the blotter paper into smaller pieces, or diluting the LSD in water and dividing the solution into microdose portions. Diluting the LSD is the best way to make each microdose more even.

Microdosing mushrooms can involve a little more prep work. The best way to get an even microdose is to grind dried mushrooms into a powder and weigh out an amount, usually around 0.1 to 0.2 grams. The powder can be taken on its own, in capsules, or added to a smoothie. Whole mushrooms can also be used, but keep in mind that different parts of the mushroom contain different amounts of psilocybin, so grinding them into a powder is best for those looking to have more control over their microdosing experience.


Many people describe the experience of microdosing mushrooms as grounding, introspective, and meditative. Microdosing LSD is typically considered a more uplifting and stimulating experience. While every individual will experience the two substances slightly differently, these distinctions seem to hold true for most microdosers.

Because of their ability to enhance self-reflection and provoke deep thinking, microdosing mushrooms might be the better choice if you’re looking to spend the day alone in nature, ask yourself difficult questions, or overcome a mental obstacle on your life path. Microdosing LSD might be the better choice if you’re looking to gain a competitive edge at work or enjoy the day with friends and family. However, the differences between these two psychedelics are slight, and you can experience a variety of benefits with each.

Some users who have tried both microdosing mushrooms and LSD report that mushrooms were better able to alleviate their depression symptoms. Those with anxiety reported that mushrooms had a more calming effect, while LSD tended to put them on edge. While these are simply anecdotal reports and the results will vary for everyone, it may be something to take into account if you’re looking to use microdosing to help with depression or anxiety.

The different durations of mushrooms and LSD should also be taken into account. Mushrooms can last four to eight hours, while LSD typically lasts six to ten hours.

Which Should I Choose?

Choosing between microdosing mushrooms and LSD can be tough, especially if you have limited experience with one or both of the substances. When making your decision, consider:

The legality and ease of obtaining each substance in your area

Your specific goals, and what you hope to get out of microdosing

Your comfort level with each substance

Ultimately, you can try microdosing both mushrooms and LSD and decide which you like better. We recommend starting with a two-week microdosing regimen using one, then taking at least a week off before starting a microdosing regimen with the other. Be sure to journal about the experience and note how you feel, think, and act throughout the process. Honest self-reflection will help you determine whether microdosing mushrooms or LSD is right for you.


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